Biography

We develop brain-machine interfaces to restore, replace, and augment nervous system function, with a particular focus on movement disorders. We use engineering approaches to leverage neural plasticity for improved interfaces, and use engineered interfaces as tools to study neural mechanisms of learning.

Our laboratory works at the intersection of engineering and neuroscience to develop therapeutic neural interfaces. The lab explores neural interfaces as adaptive closed-loop systems that engage neural plasticity and adaptation. We use engineering approaches to leverage neural adaptation for system performance, and uses neural interfaces as a tool to study neural mechanisms of learning in circuits. The lab also specializes in system integration for advancing neurotechnologies to study neural circuits in awake primates for basic science and towards human translation. We use state of the art techniques to study neural circuits during behavior, including: optogenetics, integrated multi-scale and multi-modal neural measurements/manipulations, large-scale recordings, wireless in-cage recordings, high-dimensional motion tracking, and closed-loop adaptive interfaces.

Education

• Ph.D. Bioengineering, UC Berkeley/UCSF Joint Graduate Program in Bioengineering, 2013
• Ph.D. Bioengineering, UC Berkeley/UCSF Joint Graduate Program in Bioengineering, 2013 B.S. Engineering Physics, Case Western Reserve University, 2007

Previous appointments

• Pesaran Lab, Center for Neural Science, New York University, 2014-2018

Select publications

1. J. Kleinbart, A. L. Orsborn, John S. Choi, C. Wang, S. Qiao, J. Viventi, B. Pesaran (2018) A modular implant system for multimodal recording and manipulation of the primate brain, 39th International conference IEEE EMBS, Honolulu, HI.
2. M. Shanechi*, A. L. Orsborn* (equal contribution), H.G. Moorman*, S. Gowda*, and J.M. Carmena (2017). Rapid control and feedback rates enhance neuroprosthetic control. Nature Communications, 8:13825, doi:10.1038/ncomms13825
3. A.L. Orsborn and B. Pesaran (2017) Parsing learning in networks using brain-machine interfaces, Current Opinions in Neurobiology, 46:76-83, doi: 10.1016/j.conb.2017.08.002
4. M. Shanechi , A.L. Orsborn* (equal contribution), and J.M. Carmena (2016). Robust brain-machine interface design using optimal feedback control modeling and adaptive point process filtering. PLoS Computational Biology 12(4):e1004730. doi:10.1371/journal.pcbi.1004730 (F1000 recommended)
5. A.L. Orsborn, K. So, S. Dangi, and J.M. Carmena (2013) Comparison of neural activity during closed-loop control of spike- or LFP-based brain-machine interfaces. Proceedings of the 6th International Conference IEEE EMBS Neural Engineering, San Diego, CA.
6. A.L. Orsborn, H.G. Moorman, S.A. Overduin, M. M. Shanechi, D. Dimitrov, and J.M. Carmena (2014) Closed-loop decoder adaptation shapes neural plasticity for skillful neuroprosthetic control, Neuron 82, pp. 1380-1393. (journal cover article)
7. A.L. Orsborn and J.M. Carmena (2013) Creating new functional circuits for action via brain-machine interfaces, Frontiers in Computational Neuroscience, 7:157, doi: 10.3389/fncom.2013.00157
8. S. Dangi*, A.L. Orsborn* (equal contribution), H.G. Moorman, and J.M. Carmena (2013) Design and analysis of closed-loop decoder adaptation algorithms for brain-machine interfaces. Neural Computation, 25(7), pp. 1693-1731.
9. A.L. Orsborn, S. Dangi, H.G. Moorman, and J.M. Carmena (2012) Closed-loop decoder adaptation on intermediate time-scales facilitates rapid BMI performance improvements independent of decoder initialization conditions. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 20(4), pp. 468 – 477.

Honors & awards

• Clare Boothe Luce professorship, 2018 – 2024
• L’Oréal USA for Women in Science postdoctoral fellowship, 2016
• 1st runner up, Rosalind Franklin Appathon “Best New App” for promoting women in STEMM, 2016
• International Brain-Computer Interface Meeting student travel fellowship, 2013
• American Heart Association, Western States Affiliate, Pre-doctoral fellowship, 2011
• National Science Foundation Graduate Research Fellowship, 2008
• Outstanding Senior in Engineering Physics, CWRU, 2007
• Krumhansle Family Prize for Outstanding Achievement in Physics, CWRU, 2006 and 2007
• Tau Beta Pi engineering honor society, 2005
• Fiat Awards Program Scholarship, 2004 and 2008
• Case Western Reserve University Provost Scholarship, 2003 – 2007