Daniel Chiu
Professor
Bioengineering
Joint A. Bruce Montgomery Professor
Chemistry
- chiu@uw.edu
- (206) 543-1655
- BAG 204
- Faculty Website
Biography
I am developing new technologies to address pressing needs in biomedicine. My lab is focused on developing new methods for probing complex biological processes at the single-cell and single-molecule level, and on applying these new techniques for addressing pressing biological problems.
Education
- Ph.D in Chemistry, Stanford University, 1998
- B.A. in Neurobiology, B.S. in Chemistry, University of California at Berkeley, 1993
Previous appointments
- Postdoctoral Fellow, Harvard University, 2000
Select publications
- T. Schneider, J. Kreutz, D.T. Chiu (2013) “The potential impact of droplet microfluidics in biology” Anal. Chem. 85, 3476-3482.
- C. Wu and D.T. Chiu (2013) “Semiconducting polymer dots: A new family of fluorescent nanoparticles for biological applications” Angew. Chem. Int. Ed. 52, 3086-3109.
- P.G. Schiro, M. Zhao, J.S. Kuo, T. Schneider, K.M. Koehler, D.E. Sabath, D.T. Chiu (2012) “Sensitive and high-throughput isolation of rare cells from peripheral blood with ensemble decision aliquot ranking” Angew. Chem. Int. Ed. 51, 4618-4622.
- F. Ye, C. Wu, Y. Jin, Y.H. Chan, X. Zhang, D.T. Chiu (2011) “Ratiometric temperature sensing with semiconducting polymer dots” J. Amer. Chem. Soc. 133, 8146-8149.
- C. Wu, S.J. Hansen, Q. Hou, J. Yu, M. Zeigler, Y. Jin, D.R. Burnham, J.D. McNeill, J.M. Olson, D.T. Chiu (2011) “Design of highly emissive polymer blend bioconjugates for in vivo tumor targeting” Angew. Chem. Int. Ed. 50, 3430-3434.
- S.A. Mutch, P. Kensel-Hammes, J.C. Gadd, B.S. Fujimoto, R.W. Allen, P.G. Schiro, R.M. Lorenz, C.L. Kuyper, J.S. Kuo, S.M. Bajjalieh, D.T. Chiu (2011) “A quantitative single vesicle imaging technique reveals a subset of synaptic vesicle membrane proteins are trafficked with high precision” J. Neurosci. 31, 1461-1470.
- K.A.D. Gregersen, Z.B. Hill, J.C. Gadd, B.S. Fujimoto, D.J. Maly, D.T. Chiu (2010) “Intracellular Delivery of Bioactive Molecules using Light-Addressable Nanocapsules” ACS Nano 4, 7603-7611.
- C. Wu, Y. Jin, T. Schneider, D. Burnham, and D.T. Chiu (2010) “Ultra-bright and bio-orthogonal labeling of cellular targets using semiconducting polymer dots and click chemistry” Angew. Chem. Int. Ed. 49, 9436-9440.
- C. Wu, T. Schneider, M. Zeigler, J. Yu, P.G. Schiro, D.R. Burnham, J.D. McNeill, D.T. Chiu (2010) “Bioconjugation of ultrabright semiconducting polymer dots for specific cellular targeting” J. Amer. Chem. Soc. 132, 15410-15417.
- D.E. Cohen, T. Schneider, M. Wang, D.T. Chiu (2010) “Self-digitization of sample volumes” Anal. Chem. 82, 5707-5717.
- D.T. Chiu & R.M. Lorenz (2009) “Chemistry and biology in femtoliter and picoliter volume droplets” Accounts of Chem. Res. 42, 649-658.
- J.S. Edgar, G. Milne, Y. Zhao, C.P. Pabbati, D.S.W. Lim, D.T. Chiu (2009) ”Droplet compartmentalization of chemical separations” Angew. Chem. Int. Ed. 48, 2719-2722.
- Y. Zhao, J.S. Edgar, G.D.M. Jeffries, D. McGloin, D.T. Chiu (2007) “Spin-to-orbital angular momentum conversion in a strongly focused optical beam” Phys. Rev. Lett. 99, 073901.
- S.A. Mutch, B. Fujimoto, C.L. Kuyper, J.S. Kuo, S.M. Bajjalieh, D.T. Chiu (2007) “De-convolving single-molecule intensity distributions for quantitative microscopy measurements” Biophys. J. 92, 1-18.
- G.D.M. Jeffries, J.S. Edgar, Y. Zhao, J.P. Shelby, C. Fong, D.T. Chiu (2007) “Using polarization-shaped optical vortex traps for single cell nanosurgery” Nano Lett. 7, 415-420.
- G.D.M. Jeffries, J.S. Kuo, D.T. Chiu (2007) “Dynamic modulation of chemical concentration in an aqueous droplet” Angew. Chem. Int. Ed. 46, 1326-1328.
- M. He, J.S. Edgar, G.D.M. Jeffries, R.M. Lorenz, J.P. Shelby, D.T. Chiu (2005) “Selective encapsulation of single cells and subcellular organelles into picoliter and femtoliter-volume droplets” Anal. Chem. 77, 1539–1544.
- J.P. Shelby, J. White, K. Ganesan, P.K. Rathod, D.T. Chiu (2003) “A microfluidic model for single-cell capillary obstruction by Plasmodium falciparum-infected erythrocytes” Proc. Natl. Acad. Sci. U.S.A. 100, 14618–14622.
- B. Sun and D. T. Chiu (2003) “Spatially and temporally resolved delivery of stimuli to single cells” J. Am. Chem. Soc. 125, 3702–3703.
- J. P. Shelby, D.S.W. Lim, J.S. Kuo, D.T. Chiu (2003) “Generation of ultra-high radial accelerations in microvortices” Nature 425, 38.J. P. Shelby, D.S.W. Lim, J.S. Kuo, D.T. Chiu (2003) “Generation of ultra-high radial accelerations in microvortices” Nature 425, 38.
Honors & awards
- 2011 UW Presidential Entrepreneurial Faculty Fellow
- 2010 Analytical Chemistry Young Innovator Award
- 2009 Pittcon Achievement Award
- 2007 American Chemical Society National Fresenius Award
- 2005 Alfred P. Sloan Fellow
- 2004 McKnight Technological Innovations in Neuroscience Award
- 2003 Keck Distinguished Young Scholar in Biomedical Research
- 2002 NIH Cutting-Edge Technology in Basic Research Award
- 2002 National Science Foundation Career Award
- 2000 Research Corporation’s Research Innovation Award
- 2000 Dreyfus New Faculty Award
- 2012 Elected AAAS Fellow