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Faculty & research

David G. Castner

Faculty Photo

Professor Emeritus
Bioengineering

Professor Emeritus
Chemical Engineering

Director - NESAC/BIO
Chemical Engineering

Education

  • PhD, Physical Chemistry, University of California at Berkeley, 1979
  • BS, Chemistry, Oregon State University, 1975

Select publications

  1. “Biomedical Surface Analysis: Evolution and Future Directions,” D.G. Castner, Biointerphases, 12, paper 02C301 (11 pages), 2017.
  2. “Predicting the Orientation of Protein G B1 on Hydrophobic Surfaces using Monte Carlo Simulations,” E.T. Harrison, T. Weidner, D.G. Castner and G. Interlandi, Biointerphases, 12, paper 2D401 (10 pages), 2017.
  3. “Multi-technique Characterization of Oligo(ethylene glycol) Functionalized Gold Nanoparticles,” A. Rafati, A.G. Shard and D.G. Castner, Biointerphases, 11, paper 04B304 (10 pages), 2016.
  4. “ToF-SIMS and XPS Characterization of Protein Films Adsorbed onto Bare and Sodium Styrene Sulfonate Grafted Gold Substrates,” R.N. Foster, E.T. Harrison and D.G. Castner, Langmuir, 32, 3207-3216, 2016.
  5. “Quantifying the Impact of Nanoparticle Coatings and Non-uniformities on XPS Analysis: Gold/silver Core-shell Nanoparticles,” Y.-C. Wang, M.H. Engelhard, D.R. Baer and D.G. Castner, Analytical Chemistry, 88, 3917-3925, 2016.
  6. “Differential Surface Activation of the A1 Domain of von Willebrand Factor,” E.H. Tronic, O. Yakovenko, T. Weidner, J.E. Baio, R. Penkala, D.G. Castner and W.E. Thomas, Biointerphases, 11, paper 029803 (9 pages), 2016.
  7. “A Technique for Calculation of Shell Thicknesses for Core-Shell-Shell Nanoparticles from XPS Data,” D.J.H. Cant, Y.-C. Wang, D.G. Castner and A.G. Shard, Surface and Interface Analysis, 48, 274-282, 2016.
  8. “Three-dimensional Localization of Polymer Nanoparticles in Cells using ToF-SIMS,” D.J. Graham, J.T. Wilson, J.J. Lai, P.S. Stayton and D.G. Castner, Biointerphases, 11, paper 02A304 (6 pages), 2016.
  9. “ToF-SIMS 3D Imaging of Native and Non-Native Species within HeLa Cells,” J. Brison, M.A. Robinson, D.S.W. Benoit, S. Muramoto, P.S. Stayton and D.G. Castner, Analytical Chemistry, 85, 10869-10877, 2013.
  10. “SFG analysis of surface bound proteins: A route towards structure determination,” T. Weidner and D.G. Castner, Physical Chemistry Chemical Physics, in press, 2013.
  11. “Multivariate Analysis of ToF-SIMS Data from Multicomponent Systems: The Why, When, and How,” D.J. Graham and D.G. Castner, Biointerphases, 7, 2012, paper 49.
  12. “NEXAFS Analysis of Individual Phenylalanine Orientations in Statherin Bound to Hydroxyapatite,” T. Weidner, M. Dubey, N.F. Breen, J. Ash, J. E. Baio, C. Jaye, D.A. Fischer, G.P. Drobny and D.G. Castner, J. American Chemical Society, 134, 8750-8753, 2012.
  13. “ToF-SIMS Depth Profiling of Cells: Z-correction, 3D Imaging, and Sputter Rate of Individual NIH/3T3 Fibroblasts,” M.A. Robinson, D.J. Graham and D.G. Castner, Analytical Chemistry, 84, 4880-4885, 2012.
  14. “Probing the Orientation of Electrostatically Immobilized Protein G B1 by Time of Flight Secondary Ion Spectrometry, Sum Frequency Generation and Near-edge X-Ray Adsorption Fine Structure Spectroscopy,” J.E. Baio, T. Weidner, L. Baugh, L.J. Gamble, P.S. Stayton and D.G. Castner, Langmuir, 28, 2107-2112, 2012.
  15. “Exploring the Surface Sensitivity of ToF-SIMS by Measuring the Implantation and Sampling Depths of Bin and C60 Ions in Organic Films,” S. Muramoto, J. Brison and D.G. Castner, Analytical Chemistry, 84, 365-372, 2012.
  16. “ToF-SIMS Analysis of Adsorbed Proteins: Principal Component Analysis of the Primary Ion Species Effect on the Protein Fragmentation Patterns” S. Muramoto, D.J. Graham, M.S. Wagner, T.G. Lee, D.W. Moon and D.G. Castner, Journal of Physical Chemistry C, 115, 24247-24255, 2011.
  17. “Simulation and Modeling of Self-Assembled Monolayers of Carboxylic Acid Thiols on Flat and Nanoparticle Gold Surfaces,” S. Techane, D.R. Baer and D.G. Castner, Analytical Chemistry, 83, 6704-6712, 2011.
  18. “Multi-technique Characterization of Self-assembled Carboxylic Acid Terminated Alkanethiol Monolayers on Nanoparticle and Flat Gold Surfaces,” S.D. Techane, L.J. Gamble and D.G. Castner, Journal of Physical Chemistry C, 115, 9432-9441, 2011.
  19. “A Sum Frequency Generation and Solid-State NMR Study of the Structure, Orientation and Dynamics of Polystyrene-Adsorbed Peptides,” T. Weidner, N.F. Breen, K. Li, G.P. Drobny and D.G. Castner, Proceedings of the National Academy of Sciences, 107, 13288-13293, 2010.

Honors & awards

  • 2018, Medard W. Welch Award, AVS
  • 2017, ECASIA Award
  • 2014, Rivière Prize, UK Surface Analysis Forum
  • 2003-2017 Visiting Professor, Université Paris 13
  • 2009-2011 President-Elect (09), President (10), Immediate Past President (11), American Vacuum Society
  • 2005-2007 Board of Directors, American Vacuum Society
  • 2004 Program Chair, American Vacuum Society International Symposium
  • 2004 Clemson Award for Basic Research, Society for Biomaterials
  • 2003 Excellence in Surface Science Award, Surfaces in Biomaterials Foundation
  • 2013 Fellow, American Institute of Medical and Biological Engineering (AIMBE)
  • 2004 Fellow, Biomaterials Science and Engineering
  • 1999 Fellow, American Vacuum Society